Spider-Man: Origin of the Species
On one side is Spider-Man. On the other are the Rhino, the Vulture, the Shocker, Tombstone, Electro, Mysterio and a lethal legion of his deadliest foes all in the employ of the master planner himself, Dr. Octopus. And caught in the middle? The newborn child of the Green Goblin and Menace.
Collects Amazing Spider-Man #642-647.